The Nanobiosensorics “Lendület” Group started its activity in July, 2012. Their research profile is the development and application of label-free optical biosensors, the mathematical modeling of the relevant biological and biophysical processes. The research group made important steps both in the development of their research infrastructure and both in creating its personal and collaborative network. The established - in Hungary not yet conducted - research lines are promising. In several topics (instrumental development, monitoring microvesicles, cell adhesion, flagellin based functional layers, modeling) the group could achieve strategic results, which were published in important international journals (Analytical Chemisty, Biosensors and Bioelectronics, Scientific Reports, Sensors and Actuators B, International Journal of Molecular Sciences, Langmuir, Colloids and Interfaces B, Plos One, Applied Physics Letters etc.), or are under submission.
The group has established a cell culture laboratory, making possible to launch a new and promising research line, the “label-free biosensorics of living cells”. They have installed an EPIC multichannel biosensor prototype and an M4 Holomonitor. It is important to note that both instruments are quite unique both nationally and internationally. They are among the first who can develop and apply these modern techniques. Not less importantly, the group continued its collaboration with the Swiss startup, Creoptix AG on high resolution label-free optical sensing.
It is worth mentioning that they were the first who could measure the adhesion properties of microvesicles secreted by living cells and the surface adhesion kinetics of human monocytes using label-free optical biochips. Considering cancer cell adhesion and spreading the group first established a methodology to determine the integrin receptor-RGD ligand affinity constant in living cells without applying any labelling. Their results on measuring the structural order of nanometer scale biological layers (proteins, lipid bilayers) are similarly important. These results can find further applications in biotechnology and medical diagnostics.
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